Ø limitation and provocation of T and B cells.

Ø  Introduction:

Scientific knowledge has enabled us to derive
therapy for different disorders. But many diseases still need attention regarding their definitive
treatment plan and oral submucous fibrosis is among those diseases.It is a condition having higher
propensity towards malignancy(1)

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.The habit of areca nut chewing plays a major role in disease
initiation and progression especially to those individuals who have southeast
Asian origin(2).

Chief sites affected are cheek mucousa,faucial pillar and
soft palate. Masticatory muscles and underlying muscles may also get

Various modalities for symptomatic relief have been advocated
but still no definite treatment strategy exists, because fibrosis involved in
this condition can’t be reversed(4).

Initial and extremely important measure to treat it is to
discontinue the habit and it can be done through educating the person regarding
the disease and its consequences,moral support and methods of oral hygiene

Current management options are hyaluronidase injection, intralesional
hydrocortisone, intralesional triamcinolone, extracts from placenta, lycopene ,colchicine
plus vitamin and iron supplements.

Surgical interention is
inevitable  when extreme limitation of opening
of mouth or biopsy proven dysplastic or neoplastic changes are observed.(6)


treatment and cutting of the fibrous bands of the jaw musculature and TMJ can
be used in case of severity.

Pentoxifylline is
derived from methylxanthine and has shown good results in OSMF treatment  due to it’s discrete effects like modification
of physiology of fibroblasts ,fibrinolysis and anti-inflammatory characteristics.

Other actions of Pentoxifylline are peroxide
degranulation and release, increase in natural killer cells(NK) activity,tumor
necrosis factor(TNF) production limitation and provocation of T and B cells.


Hence anti-inflammatory and immune
regulating actions of pentoxifylline may have therapeutic advantages  for OSMF management.(7)

The purpose of my study is to evaluate
the efficacy of this relatively newer drug in the management