Flucytosine the organism to produce ? – (1, 3)

Flucytosine  Flucytosine, also knownas 5-fluorocytosine (5-FC), is an antifungalmedication.Flucytosine taken orally isused  in the therapy of severe infectionsthat are cause by strains of Candida or Cryptococcusneoformans. It may also beused in the therapy plan of chromomycosis (chromoblastomycosis) Chemistry: Fluorinated pyrimidine like5-Fluorouracil How they work? They are Anti-fungal having fungi staticeffect.1.    They are taken up by the fungal cells2.    Then they are Deaminated to 5-FU3.    Then Merged  as FUTP in RNA4.

    5-FdUMP  (which is an Inhibitor of thymidylate synthetase)Cytosine deaminase is absent in mammals, so humansare not affected.Effective in treating: a.      Cryptococcusneoformans , b.      Candida spp          Echinocandins aspofungin,micafungin, and anidulafungin three types of echinocandins and they are  semisynthetic echinocandin end products withclinical uses because of  theirsolubility, antifungal action, and pharmacokinetic properties.

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 They havefungistatic action against Aspergillus kinds. And fungicidal actionagainst most Candida spp.  Chemistry  Big cyclic chemical compounds with a longchain of fatty acids.    How they work ? The echinocandins work as antifungal by inhibiting ? – (1, 3) -D-glucan synthase, which is an necessary component of the fungal cell wallwhere it’s absent in mammals. Incapability of the organism to produce ? – (1,3) – D-glucan will evantually leads to osmotic instability and cell death. Effective in treating   a.

      Candida albicans, b.       C glabrata, c.       C tropicalis,d.      C krusei,e.

       Aspergillusfumigatus, f.        A  flavus,g.       A terreush.      Pneumocystis  jiroveci**