Flucytosine Flucytosine, also knownas 5-fluorocytosine (5-FC), is an antifungalmedication.Flucytosine taken orally isused in the therapy of severe infectionsthat are cause by strains of Candida or Cryptococcusneoformans. It may also beused in the therapy plan of chromomycosis (chromoblastomycosis) Chemistry: Fluorinated pyrimidine like5-Fluorouracil How they work? They are Anti-fungal having fungi staticeffect.1. They are taken up by the fungal cells2. Then they are Deaminated to 5-FU3. Then Merged as FUTP in RNA4.
5-FdUMP (which is an Inhibitor of thymidylate synthetase)Cytosine deaminase is absent in mammals, so humansare not affected.Effective in treating: a. Cryptococcusneoformans , b. Candida spp Echinocandins aspofungin,micafungin, and anidulafungin three types of echinocandins and they are semisynthetic echinocandin end products withclinical uses because of theirsolubility, antifungal action, and pharmacokinetic properties.
They havefungistatic action against Aspergillus kinds. And fungicidal actionagainst most Candida spp. Chemistry Big cyclic chemical compounds with a longchain of fatty acids. How they work ? The echinocandins work as antifungal by inhibiting ? – (1, 3) -D-glucan synthase, which is an necessary component of the fungal cell wallwhere it’s absent in mammals. Incapability of the organism to produce ? – (1,3) – D-glucan will evantually leads to osmotic instability and cell death. Effective in treating a.
Candida albicans, b. C glabrata, c. C tropicalis,d. C krusei,e.
Aspergillusfumigatus, f. A flavus,g. A terreush. Pneumocystis jiroveci**