AbstractIntroduction: Depression is one of the commonest psychiatric disorder in today’sera worldwide. According to the National Institute of Mental Health, majordepressive disorder is characterized by a combination of symptoms thatinterfere with a person’s ability to work, sleep, study, eat, and enjoyonce-pleasurable activities.

Depression is not directly described in Ayurvedictexts but similar conditions named “Avasada” and “Vishada” are observed.  The synthetic antidepressant drugs are provedto be of a great benefit in this illness, but have many limitations besidestheir serious side effects including the problem of addiction and drug abuse. Hencethere is a need to discover indigenous drugs for this condition, which are provedless harmful. Aims & objective: To collect information of variousMedicinal herbs proven Anti Depressive.

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Material & Methods: In the present study variousarticles, Journals and Textbooks concern of Medicinal herbs in Depression are scrutinized.Observations & Results: The present study reveals thatthere are various Medicinal Herbs which are proven as anti depressant with helpof experimental and clinical studies. Medicinal Herbs like Ashvagandha (Withania somnifera), Kapikachhu (Mucuna pruriens),Vacha (Acorus calamus), Nagarmotha (Cyperus rotundus), Hypericum mysoresne– Folklore plant, Tamalpatra (Cinnamomum tamala), Yastimadhu (Glycyrrhizaglabra), Maricha (Piper nigrum), Bibhitaki (Terminalia bellerica), Kaidarya (MurrayaKoienegi), Bramhi (Bacopa monniera), Jyotishmati(Celastrus paniculatus), Vishnukrantha(Evolvulus alsinoides), Sahadevi (Vernonia cineria) etc. are found to be evaluated for  anti depressive action. Inthis context of various herbal drugs appear to be of potential value in thetreatment of depression.Conclusion:Various Medicinal herbs are observed having antidepressant activity and can beused in Depression to overcome the side effects of synthetic antidepressant drugs.Keywords: Depression, anti depressant activity, Avasada, Visada